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D2043
Sigma
Defensin HNP-1 human
≥80% (HPLC)
| Synonym: | Neutrophil Peptide-1 |
| Amino Acid Sequence: | Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide bridges: 2−30; 4−19; 9−29] |
| CAS Number: | 99287-08-8 |
| Linear Formula: | C150H222N44O38S6 |
| Molecular Weight: | 3442.03 |
| MDL number: | MFCD00214572 |
Description
| Biochem/physiol Actions | This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds. |
Properties
| assay | ≥80% (HPLC) |
| composition | Peptide content, ~70% |
| Gene Information | human ... DEFA1(1667) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Ouellette A.J., IV Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am. J. Physiol. 277, G257-G261, (1999) Abstract |
| Hiemstra P.S., et al., Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Eur. Respir. J. 12, 1200-1208, (1998) Abstract |
